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While it's not known regardless of whether other unfamiliar interactions are happening on the receptor that contribute to its effects, the receptor plays a role being a unfavorable down regulator of endogenous opiate concentrations by means of scavenging activity. This drug-receptor interaction presents a substitute for manipulation in the classica… Read More

Importantly, these receptors have been found to are actually activated by a variety of endogenous opioids in a concentration comparable to that noticed for activation and signaling of classical opiate receptors. Consequently, these receptors were discovered to acquire scavenging action, binding to and decreasing endogenous amounts of opiates access… Read More